Route 50, The George Washington Highway, West Virginia.
How do you feel about lots of twists and turns? What a crazy question ... motorcycles were MADE for twists and turns.
Mountains ... check. Rivers ... check. Scenery ... check.
On the George Washington Highway, you'll ride just north of the beautiful Monongahela National Forest, and pass Cathedral State Park along the way too (which is a nice midway point stop).
And there's an added bonus -- once you've finished this adventure you are right there for two more of the East Coast's best rides -- Skyline Drive and The Blue Ridge Parkway!