Snakehunter Dusty Crum wages war on thousands of invasive pythons killing the Everglades, backed by his one-of-a-kind team.
Rival snake hunters encroach on Dusty's hunting spot, so he and his team take a major risk by day and night hunting deep in the dangerous Sawgrass Plains.
Dusty and his team mount a critical hunt from a swamp buggy before racing south to the python-infested Ten Thousand Islands.
Dusty leads the team to an abandoned missile factory near the epicenter of the snake epidemic that could hold the biggest concentration of pythons in the Everglades.
Dusty and team discover a frightening new hybrid Python species when they trek deep into the dense Python Pines to prevent the snakes from laying their eggs.
When a potentially record-breaking python escapes Dusty's grasp, his obsession to catch it brings him face to face with the massive reptile in the most dangerous solo mission of his career.